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Recent News

N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease

Alzheimer's disease (AD) symptoms reflect synaptic dysfunction and neuron death. Amyloid-β oligomers (AβOs) induce excess calcium entry into neurons via N-methyl-D-aspartate receptors (NMDARs), contributing to synaptic dysfunction. The study described here tested the hypothesis that AβO-stimulated calcium entry also drives neuronal cell cycle reentry (CCR), a prelude to neuron death in AD. Read More

Consent recommendations for research and international data sharing involving persons with dementia

Consent is generally required for research and sharing rich individual-level data but presents additional ethical and legal challenges where participants have diminished decision-making capacity. We formed a multi-disciplinary team to develop best practices for consent in data-intensive dementia research. We recommend that consent processes for research and data sharing support decision-making by persons with dementia,… Read More

Reduce the burden of dementia now

Although Congress has allocated substantial funding to accelerate dementia research, nearly all attempts to find effective preventions and treatments for dementia have failed. Current dementia therapies offer little hope. They provide only modest clinical benefits and have limited impact on the unrelenting progression of disease. With few means to slow the epidemic, the projected increase… Read More

Biomarkers of agitation and aggression in Alzheimer's disease: A systematic review

Agitation is one of the most challenging neuropsychiatric symptoms to treat in Alzheimer's disease and has significant implications for patient and caregiver. A major source of difficulty in identifying safe and effective treatments for agitation is the lack of validated biomarkers. As such, patients may not be appropriately targeted, and biological response to pharmacotherapy cannot… Read More
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